Wüthrich has held numerous endowed lectureships and visiting faculty appointments in the USA, Japan, India and Europe. He is a Foreign Associate of the US National Academy of Sciences, a Foreign Fellow of the Indian National Science Academy and a Member of the Deutsche Akademie der Naturforscher Leopoldina. The numerous recognitions for his work include the Stein and Moore Award, the Louisa Gross Horwitz Prize, the Marcel Benoist Prize, the Prix Louis Jeantet de Medicine and most recently, the Nobel Prize in Chemistry 2002.

The volume presents a survey of the research by Kurt Wüthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.

Contents:

• NMR and Structural Biology
• The Avenue to Three-Dimensional Protein Structure Determination in Solution
• Establishing Credibility for NMR Structures of Proteins
• Evolution of NMR Structure Determination with Biological Macromolecules 1985–94
• Selected NMR Structure Determinations
• Conformational Equilibria and Internal Mobility in Proteins in Solution
• Hydration of Proteins and Nucleic Acids in Solution
• Protein Folding
• appendices, an author index and a subject index