edited by E Jabbari (University of South Carolina, USA) & A Khademhosseini (Harvard-MIT, USA)

Table of Contents (37k)
Chapter 1: Engineering the Tissue Extracellular Matrix with Hybrid Biomaterials (265k)

Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field.

This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials.

There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

• Synthesis, Characterization and Self-Assembly:
  • Bulk and Solution Properties of Peptide-Polymer Conjugates (A Carlsen et al.)
  • Polymer-Peptide Conjugate Networks: Formation, Swelling and Degradation (D L Elbert)
  • Peptide Self-Assembly Biomaterials Design and Application (X-J Zhao et al.)
  • Micropatterned Polymer Structures for Cell and Tissue Engineering (K-J Jang et al.)
  • Synthesis and in vitro/in vivo Response to Peptide-Polymer Conjugates (A S Chung & W-Y J Kao)
• Hybrid Biomaterials in Drug Delivery and Molecular Recognition:
  • Synthesis of Multi-Epitopic Glycopeptide-Based Cancer Vaccines (O Renaudet et al.)
  • Stimuli-Sensitive Particles for Drug Delivery (S J Grainger & M E H El-Sayed)
  • Design and Synthesis of Endosomolytic Conjugated Polyaspartamide for Cytosolic Drug Delivery (K Seo & D Kim)
  • Engineering of Cell-Penetrating Peptide-Conjugated Intracellular Delivery Systems (R R Sawant & V P Torchilin)
• Cell Responsive Biomaterials in Tissue Engineering:
  • Biomimetic Matrices for Integrin-Mediated Cell Adhesion (K M Ashe et al.)
  • Engineering Artificial Stem Cell Niches (M P Lutolf)
  • Engineering Peptides in Hydrogels for Cartilage Tissue Regeneration (Z-Y Ye & J Elisseeff)
  • Biomimetic Materials for Engineering of Neural Tissues: Control of Cell Adhesion and Guiding Neural Cell Outgrowth with Peptide-Conjugated Polymer Structures (J-M Li & R-Y Shi)
  • Hybrid Biomaterials for Engineering Vascular Tissues (T C Flanagan et al.)
  • Dynamic Cell Culture Methods for Functionalized Biomaterials (B C Landy & V I Sikavitsas)