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    A PORTRAIT OF THE IMMUNE SYSTEM
    Scientific Publications of N K Jerne

    edited by Ivan Lefkovits (Basel Institute for Immunology, Switzerland)

    Ivan Lefkovits was born in 1937 and educated in Prague where he worked at the Academy of Sciences. He has lived in Italy, where he worked at the International Laboratory of Genetics and Biophysics, Naples. In 1967 he joined Niels Jerne at the Paul Ehrlich Institute in Frankfurt. In 1969 he became a founding member of the Basel Institute for Immunology, which was created by the pharmaceutical company Hoffmann-La Roche Ltd., Basel, who had the good sense to appoint Niels Jerne as the first director of the Institute; Ivan Lefkovits was a close friend and colleague of Niels Jerne throughout the years in Frankfurt and Basel, and also after Niels Jerne's retirement in south of France.


    Using the published work of Nobel Laureate Niels Kaj Jerne, this book shows how he developd his ideas. The book is a compilation of his published work, but in fact it is much more than that. Whether the reader wants to read the book systematically, or only browse, it opens a fascinating world of hypotheses, theories, facts and vistas. His selection theory, his view of how immunological diversity is created, and his concept of lymphocytes interacting as a network, reveals Jerne's revolutionary spirit. The book ought to be a rich source of inspiration for everyone interested in science and how science is made.

     
    Contents:
    • Preface:
      • The Master and His Atelier (G Stent)
    • Overview:
      • A Portrait of the Immune System (I Lefkovits)
    • On the Writing of a Paper with N K Jerne by Antonio et al.
    • Bibliography
    • Facsimiles of Selected Publications:
      • A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antioxin Mixtures (N K Jerne)
      • The Natural-Selection Theory of Antibody Formation (N K Jerne)
      • Immunological Speculations (N K Jerne)
      • Plaque Formation in Agar by Single Antibody-Producing Cells (N K Jerne & A A Nordin)
      • The Natural Selection Theory of Antibody Formation
      • Ten Years Later, in: “Phage and the Origins of Molecular Biology” (N K Jerne)
      • The Somatic Generation of Immune Recognition (N K Jerne)
      • The Immune System (N K Jerne)
      • Towards a Network Theory of the Immune System (N K Jerne)
      • Idiotypic Networks and Other Preconceived Ideas (N K Jerne)
      • The Generative Grammar of the Immune System (N K Jerne)
      • and other papers
    • Introductions to the BII Annual Reports
    • Handwritten Letters
    • Postscript (I Lefkovits)
     
    Readership: Biological scientists, immunologists and medical doctors.
     
    “This volume will be welcomed by the whole immunological community but in particular by all those immunologists who had the luck to have been co-workers of Niels Jerne or simply to have been acquainted with him. His exceptional personality and his capacity for original thinking, have made an enormous impact on modern immunology.”
    Immunological Investigation
     
    878pp    Pub. date: Dec 1996  
    ISBN:   978-981-02-2605-3
    981-02-2605-5
       US$156 / £110

     


    878pp    Pub. date: Dec 1996  
    ISBN:   978-981-02-2614-5(pbk)
    981-02-2614-4(pbk)
       US$76 / £54

     


     

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    Updated on 19 March 2010