edited by Aaron J Ciechanover (Technion-Israel Institute of Technology, Israel) & Maria G Masucci (Karolinska Institutet, Sweden)

About the Editors
Table of Contents (7k)
Preface (65k)
Learning Environments Research: Yesterday. Today and Tomorrow (46k)

Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.

This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.

• The Ubiquitin System and Some of Its Roles in Cell Cycle Control (A Hershko)
• The Ubiquitin System and the N-End Rule Pathway (A Varshavsky)
• Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis (M Tyers et al.)
• The 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis (W Baumeister & P Zwickl)
• Mechanisms and Regulation of Ubiquitin-Mediated, Limited Processing of the NF-κBα Precursor Protein p105 (A Ciechanover et al.)
• Regulation of Receptor Tyrosine Kinases by Ubiquitination (A Citri & Y Yarden)
• Regulation of p27 Degradation (J Bloom & M Pagano)
• Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction and Effects of Oxidative Stress (C M Alves dos Santos & G J Strous)
• Inhibition of the Ubiquitin-Proteasome System by a Viral Repetitive Sequence (N P Dantuma & M G Masucci)
• Autosomal Recessive Juvenile Parkinsonisms and the Ubiquitin Pathway (K Tanaka et al.)