CONFORMATIONAL PROTEOMICS OF MACROMOLECULAR ARCHITECTURE
Approaching the Structure of Large Molecular Assemblies and Their Mechanisms of Action
(With CD-ROM)
edited by R Holland Cheng (Karolinska Institutet, Sweden)
&
Lena Hammar (Karolinska Institutet, Sweden)
About the EditorsR Holland Cheng obtained his PhD in Structural Biology in 1992 at Purdue University. He is currently Director of the Institutional Program for Proteome Imaging, Karolinska Institutet. Through the years, Dr Cheng has received numerous awards, including: Outstanding Scientists for the 21st Century, International Biographical Center, Cambridge, 2001; Human Sciences Foundation of Japan, Tokyo, 1998; Young Investigator Award on Computational Biology, New York, 1995; Electron Microscopy Society of America, Presidential Award, Boston, 1992. Lena Hammar obtained her PhD in Biochemistry in 1977 at Uppsala University. She continued research and teaching in Uppsala until the mid 1990th when she joined The Karolinska Institute; her present work concerns the structure and biochemistry of viruses.
Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this important book presents cutting-edge knowledge in the various fields of structural proteomics of very large molecular assemblies, with the focus on their mechanisms of action.
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