This important book presents review articles on the cell biology of photoreceptor and RPE cells, as well as the relationship between this cell biology and inherited photoreceptor degeneration. The chapters have been written by leaders in the field. The vision scientist will see this book as a review of photoreceptor and RPE cell biology, and known molecular bases of many forms of retinitis pigmentosa and related retinal degeneration. For the cell biologist, there are articles on topics such as protein targeting, molecular motors, and phagocytosis placed in the functional context of two of the most specialized cells in the body.

This book has been selected for coverage in:
• CC / Clinical Medicine
• Neuroscience Citation Index®
• Index to Scientific Book Contents® (ISBC)

Contents:

• Cell Biology of Photoreceptors and the RPE: A Brief Introduction (D S Williams)
• Crumbs-Dependent Epithelial Organization in Retinal Morphogenesis and Disease (D F Ready & U Tepass)
• From the Golgi to the Rod-Outer Segment: Formation, Movement, Docking and Fusion of Rhodopsin Transport Carriers (D Deretic)
• Insights on Retinal Degeneration: Molecular Basis of Polarized Rhodopsin Transport (C-H Sung & J-Z Chuang)
• Targeting of Visual Pigments to Rod Outer Segment in Rhodopsin Knockout Mice (G Shi et al.)
• Photoreceptors and Intraflagellar Transport (S A Baker et al.)
• Myosin III in Photoreceptors: What Does It Do? (A Dosé et al.)
• Light-Dependent Translocation of Signaling Proteins in Vertebrate and Invertebrate Photoreceptors (K J Strissel et al.)
• Centrins, Potential Regulators of Transducin Translocation in Photoreceptor Cells (A Gießl et al.)
• The RP1 Gene and Protein in Photoreceptor Biology (S Achenbach et al.)
• Molecular Organization of Rod Outer Segments (R S Molday)
• Biochemistry and Cell Biology of the Visual Cycle (J C Saari)
• Role of Mertk in RPE Phagocytosis and Retinal Disease (D Vollrath & W Feng)
• Roles of Integrin Receptors in the Daily Phagocytosis of Photoreceptor Outer Segment Fragments by the RPE (E F Nandrot & S C Finnemann)
• Myosin VIIa in the Retina (D S Williams & D Gibbs)