This is the first book that provides a comprehensive review of the entire area of artificial cells. The author, a pioneer of the field, invented the first artificial cells some 50 years ago and has continued to carry out active research in this field. Since then, there have been explosive research activities around the world on artificial cells, especially in fields related to biotechnology, nanomedicine, cell therapy, blood substitutes, drug delivery and others. However, instead of the term “artificial cells,” many authors use other terminologies such blood substitutes, bioencapsulation, liposomes, nanoparticles, and so on. As a result, any meaningful literature search for a complete idea of the present status of the whole field of artificial cells is impossible. Furthermore, the fact that papers in this highly interdisciplinary area are published in numerous journals specializing in chemistry, medicine, surgery, bioengineering, and others, makes literature search even more difficult. Books in this area are mostly multi-authored, describing very specific and narrow areas. Therefore, many who enter this field for the first time cannot find any book that describes laboratory methods and procedures needed for starting their research.

This monograph is written to fill this gap. Based on his 50 years of work and an interdisciplinary background, the author has managed to include all those areas in artificial cells that are disguised under different terminologies. Since this is a very large area, he starts each chapter by giving a detailed overview and has included more than 1000 references to facilitate easier literature search of this highly interdisciplinary area. Detailed examples of the author's own research are given and methods and procedures are described in detail. Readers interested in a detailed overview of the whole area can read from cover to cover but omitting the methods section at the end of each chapter. On the other hand, those entering this area of research will find the detailed methods and procedures very useful.

Contents:

• 50th Anniversary of Artificial Cells
• Basic Principles
• Oxygen Carriers Based on Nanobiotechnology
• A Nanobiotechnologic Therapeutic that Transports Oxygen and Remove Oxygen Radicals: For Stroke, Hemorrhagic Shock and Related Conditions
• Nanotechnology-Based Artificial Red Blood Cells (RBCs)
• Use of Enzyme Artificial Cells for Genetic Enzyme Defects that Increase Systemic Substrates to Toxic Levels
• Enzyme Artificial Cells in Substrate-Dependent Tumors and Activation of Prodrug
• Artificial Cells for Cell Encapsulation
• Artificial Cells Containing Hepatocytes and/or Stem Cells in Regenerative Medicine
• Hemoperfusion in Poisoning, Kidney Failure, Liver Failure, and Immunology
• Perspectives on the Future of Artificial Cells as Suggested by Past Research

“This volume is the most comprehensive review of the field of artificial cells and associated fields published to date. It refreshes the knowledge of the experts while informing the naive of the history and promise of the future. Written in a conversational style and very well illustrated for fact and emphasis, it is an easy and informative read. Presented in easily accessible form are the underlying theories and concepts of artificial cells, blood substitutes, nanomedicine, regenerative medicine and stem cell therapy in the context of specific clinical situations ranging from general to very specific diseases. Basic science observations support the tested or proposed clinical applications in an exact manner. This volume contains a near encyclopedia quantity of information, carefully and logically assembled and presented. Future developments in the field will depend on the essential information presented here. An essential read for anyone interested in this field, the vision and foresight of this senior scientist and leading statesman of the field makes the topic accessible and understandable.”