PROTEIN BIOSEPARATION USING ULTRAFILTRATION
Theory, Applications and New Developments
by Raja Ghosh (McMaster University, Canada)
Table of Contents (52k)
Preface (55k)
Chapter 1: Protein Bioseparation: An Overview (115k)
Raja Ghosh holds a doctorate degree in Engineering Science from Oxford University. H has been a lecturer at Oxford University since 1998. He teaches Chemical Engineering and his research interests are in the field of membrane science and technology. He has published several research papers and reviews on bioseparation using membrane technology in journals including AIChE Journal, Biotechnology & Bioengineering, Journal of Chromatography A and Journal of Membrane Science.
Ultrafiltration is a pressure-driven, membrane-based separation process, which is used for a broad variety of applications, ranging from the processing of biological macromolecules to wastewater treatment. It has significant advantages over competing separation technologies. Food and biotechnological applications account for nearly 40% of the current total usage of ultrafiltration membranes. Protein bioseparation is an important component of this application segment. Ultrafiltration is used for protein concentration, desalting, clarification and fractionation (i.e. protein–protein separation). Concentration, desalting and clarification are technologically less demanding and have been in used in the bioprocess industry for some time. Protein fractionation, on the other hand, is a challenging proposition and is definitely a more recent development. This book focuses primarily on protein fractionation.
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