edited by Carlos Gitler (Weizmann Institute of Science, Israel) & Avihai Danon (Weizmann Institute of Science, Israel)

About the Editors

Professor Carlos Gitler holds the E Stanley Enlund Chair of Membrane Research.
 

Professor Avihai Danon holds The Judith and Martin Freedman Career Developmental Chair. A grant from Dorot Science Fellowships Foundation and grant from Minerva Foundation supported this work.

Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved.

This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells.

• The Role of Thioredoxin and Glutaredoxin Systems in Disulfide Reduction and Thiol Redox Control
• Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling
• Iron–Sulfur Proteins: Properties and Functions
• The Ferredoxin Ferredoxin/Thioredoxin Thioredoxin System. A Light-Dependent Redox Regulatory System in Oxygenic Photosynthetic Cells
• Thioredoxin and Redox Regulation: Beginnings in Photosynthesis Lead to a Role in Germination and Improvement of Cereals
• The Role of Thioredoxin in Regulatory Cellular Functions
• Protein S-Thiolation, S-Nitrosylation, and Irreversible Sulfhydryl Oxidation: Roles in Redox Regulation
• Radical Scavenging by Thiols: Biological Significance and Implications for Redox Signaling and Antioxidant Defense
• Ascorbate and Glutathione Metabolism in Plants: H₂O₂-Processing and Signaling
• Disulfide Bond Formation in the Periplasm and Cytoplasm of Escherichia Coli
• The Thiol Redox Paradox in the Requirement for Disulfide Isomerization in the Eukaryotic Endoplasmic Reticulum
• Mechanisms Controlling Redox Balance in Cells. Inhibition of Thioredoxin and of Thioredoxin Reductase
• Regulatory Disulfides Controlling Transcription Factor Activity in the Bacterial and Yeast Responses to Oxidative Stress
• Redox Signaling During Light-Regulated Translation in Chloroplasts
• Regulation of mRNA Translation and Stability in Iron Metabolism: Is There a Redox Switch?
• Redox Flow as an Instrument for Gene Regulation
• The Permeability Transition Pore as Source and Target of Oxidative Stress