edited by Jonathan Arthur (University of Sydney, Australia) & See-Kiong Ng (Institute for Infocomm Research, Singapore)

This volume contains papers presented at the 19th International Conference on Genome Informatics (GIW 2008) held at the Marriott Surfers Paradise Resort, Gold Coast, Queensland, Australia from December 1 to 3, 2008. The GIW Series provides an international forum for the presentation and discussion of original research papers on all aspects of bioinformatics, computational biology and systems biology. Its scope includes biological sequence analysis, protein structure prediction, genetic regulatory networks, bioinformatic algorithms, comparative genomics, and biomolecular data integration and analysis. Boasting a history of 19 years, GIW is the longest-running international bioinformatics conference.

A total of 18 contributed papers were selected for presentation at GIW 2008 and for inclusion in this book. The selected papers come from institutions in 18 countries. In addition, this book contains abstracts from the six invited speakers: Sean Grimmond (Institute for Molecular Bioscience, The University of Queensland, Australia), Eugene V Koonin (National Center for Biotechnology Information, National Institutes of Health, USA), Ming Li (University of Waterloo, Canada), Yi-Xue Li (Chinese Academy of Sciences and Shanghai Jiaotong University, China), John Mattick (Institute for Molecular Bioscience, The University of Queensland, Australia), and Eric Schadt (Rosetta Inpharmatics, USA).

• An Approach to Transcriptome Analysis of Non-Model Organisms Using Short-Read Sequences (L J Collins et al.)
• Factoring Local Sequence Composition in Motif Significance Analysis (P Ng & U Keich)
• A New Model of Multi-Marker Correlation for Genome-Wide Tag SNP Selection (W B Wang & T Jiang)
• Phenotype Profiling of Single-Gene Deletion Mutants of E. coli Using Biolog Technology (Y Tohsato & H Mori)
• Improved Algorithms for Enumerating Tree-Like Chemical Graphs with Given Path Frequency (Y Ishida et al.)
• BSAlign: A Rapid Graph-Based Algorithm for Detecting Ligand-Binding Sites in Protein Structures (Z Aung & J C Tong)
• Protein Complex Prediction Based on Mutually Exclusive Interactions in Protein Interaction Network (S H Jung et al.)
• On the Reconstruction of the Mus musculus Genome-Scale Metabolic Network Model (L-E Quek & L Nielsen)
• Predicting Differences in Gene Regulatory Systems by State Space Models (R Yamaguchi et al.)
• Exploratory Simulation of Cell Ageing Using Hierarchical Models (M Cvijovic et al.)
• Inferring Differential Leukocyte Activity from Antibody Microarrays Using a Latent Variable Model (J W K Ho et al.)
• Assessing and Predicting Protein Interactions Using Both Local and Global Network Topological Metrics (G Liu et al.)
• Modeling the Evolution of Protein Coding Sequences Sampled from Measurably Evolving Populations (M Goode et al.)
• A Phylogenomic Approach for Studying Plastid Endosymbiosis (A Moustafa et al.)
• Cis-Regulatory Element Based Gene Finding: An Application in Arabidopsis thaliana (Y Li et al.)
• Using Simple Rules on Presence and Positioning of Motifs for Promoter Structure Modeling and Tissue-Specific Expression Prediction (A Vandenbon & K Nakai)
• Improving Gene Expression Cancer Molecular Pattern Discovery Using Nonnegative Principal Component Analysis (X Han)
• Simulation Analysis for the Effect of Light-Dark Cycle on the Entrainment in Circadian Rhythm (N Mitou et al.)