edited by Yuriy Gusev (University of Oklahoma, USA)

The recent discovery of microRNAs — a new class of non-coding RNAs — has revolutionized modern biomedical sciences. This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology and mathematical modeling.

This volume contains adaptations and critical reviews of the recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of miRNA regulation are also discussed.

• Measurement and Interpretation of MicroRNA Expression Profiles (B Curry & R Ach)
• MicroRNA Expression Analysis by LNA Enhanced Microarrays (R Søkilde et al.)
• Analysis and QC for Real-Time QPCR Arrays of Human MicroRNAs (D P Dittmer et al.)
• Massively Parallel MicroRNA Profiling in the Haematologic Malignancies (R D Morin et al.)
• Who Dunit? MicroRNAs Involved in Prostate Cancer (H K Chang)
• Intronic MicroRNA: Creation, Evolution and Regulation (S Barik & T Barik)
• MiRome Architecture and Genomic Instability (K Huppi et al.)
• Interconnection of MicroRNA and Transcription Factor-Mediated Regulatory Networks (Y-M Zhou)
• Analysis of MicroRNA Profiling Data with Systems Biology Tools (Y Gusev et al.)
• Mathematical and Computational Modeling of Post-Transcriptional Gene Regulation by MicroRNAs (R Khanin & D J Higham)