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HUMAN BLOOD CELLS
Consequences of Genetic Polymorphisms and Variations
edited by May-Jean King (International Blood Group Reference Laboratory)
This important book uses selected molecules expressed on erythrocytes, lymphocytes, platelets and granulocytes to illustrate how genetic polymorphisms and variations in these molecules can affect their structure and function in mature human blood cells. The examples described tend to have a clinical association. Human blood group antigens and HLA antigens are classic examples of genetic polymorphism and they are important in blood transfusion and organ transplantation, respectively. In common with the blood group antigens, the polymorphic and variant antigens on platelets and granulocytes can be targets for antibodies in feto-maternal antigen incompatibility and transfusion reactions. Certain inherited haemolytic anaemias can be attributed to some of the polymorphic and variant forms of erythrocyte anion transport protein, spectrin, and glucose-6-phosphate dehydrogenase which exhibit abnormal structural or functional properties. Similarly, the study of cytokine gene polymorphism can provide a further understanding of the immune/inflammatory diseases and allogeneic transplantation.
Contents:
- An Introduction to Genetic Polymorphism (D Hopkinson & D
Whitehouse)
- ABO Polymorphisms and Their Putative Biological Relationships with Disease (S Henry & B Samuelsson)
- Molecular Biology of the Rh Blood Group Polymorphisms (N D Advent)
- Structure, Polymorphisms and Biological Role of Glycophorins A, B, C, and D (M-J King)
- Contribution of Band 3 and Its Genetic Polymorphisms and Variants to Health and Disease (M M B Kay)
- Spectrin Polymorphisms and Low-Expressed a-Spectrin Alleles in Hereditary Elliptocytosis and Hereditary Spherocytosis (D Dhermy)
- Genetic Variation of Human Erythrocyte Glucose-6-Phosphate Dehydrogenase (P Mason & T Vulliamy)
- HLA Polymorphism (J Ross & J Harvey)
- Polymorphisms of Platelet Glycoproteins — Molecular Basis and Clinical Consequences (P Metcalfe)
- Molecular Basis, Function and Clinical Significance of Granulocyte Glycoprotein Polymorphisms (G Lucas)
- Cytokine Gene Polymorphism (J L Bidwell et al.)
Readership: Biomedical science students at MSc level and research scientists
in haematology.
| 420pp |
Pub. date: Jul 2000 |
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