edited by Andreas Luch (Massachusetts Institute of Technology, USA)

This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs.

• Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis — An Introduction (A Luch)
• Metabolic Activation and Detoxification of Polycyclic Aromatic Hydrocarbons (A Luch & W M Baird)
• Biomonitoring of Polycyclic Aromatic Hydrocarbons — Human Exposure (A Seidel)
• Macromolecular Adducts as Biomarkers of Human Exposure to Polycyclic Aromatic Hydrocarbons (D H Phillips)
• DNA Damage and Mutagenesis Induced by Polycyclic Aromatic Hydrocarbons (A Besaratinia & G P Pfeifer)
• Mechanisms of Repair of Polycyclic Aromatic Hydrocarbon-Induced DNA Damage (H Naegeli & N E Geacintov)
• Aberrant Gene Expression and Cell Signalling/Epigenetic Effects Induced by Polycyclic Aromatic Hydrocarbons (P Steinberg)
• Indicator Assays for Polycyclic Aromatic Hydrocarbon-Induced Genotoxicity (H Glatt)
• Tumorigenicity of Polycyclic Aromatic Hydrocarbons (S Amin & K El-Bayoumy)
• Genetic Susceptibility to Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis (A Hirvonen)
• Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis — An Integrated View (A Luch)