edited by Keshav K Singh (Roswell Park Cancer Institute, USA)

This book aims to provide a comprehensive review of the most up-to-date knowledge of the sources and molecular mechanisms of oxidative stress, and its role in disease and cancer. It also focuses on the novel agents and methods that can be employed to prevent oxidative stress and associated diseases.

The authors first review the most recent data on the basic mechanisms of oxidative stress. The second section discusses oxidative stress leading to several diseases and cancers, and in the third section, the strategies employed in the prevention and treatment of oxidative stress-related diseases are discussed.

• Yin and Yang of Mitochondrial ROS (A Starkov & K B Wallace)
• Intracellular Oxidative Stress Caused by Ionizing Radiation (H J Majima et al.)
• Oxidative Damage to Mitochondria (J C Tilak & T P A Devasagayam)
• Oxidative Stress and Antioxidant Defenses in Plants (O Blokhina & K Fagerstedt)
• Lipid- and Protein-Mediated Oxidative Damage to DNA (M D Evans & M S Cooke)
• Oxidative Damage to Nucleotide: Consequences and Preventive Mechanisms (Y Nakatsu & M Sekiguchi)
• Oxidative Damage to DNA and Its Repair (L J Rasmussen)
• Cellular Responses to Reactive Oxygen Species (I W Dawes)
• Oxidative Stress, Cell Proliferation, and Apoptosis (J S Carew et al.)
• Oxidative Damage to Carbohydrates and Amino Acids (M d'Ischia et al.)
• Superoxide Dismutase 2 Deficient Mice: The Role of Increased Reactive Oxygen Species in Genomic Instability (E Samper et al.)
• Oxidative Stress, Genetic Variation, and Disease (L Lyrenäs et al.)
• Oxidative Stress and Autoimmune Diseases (J Saegusa et al.)
• Does Oxidative Stress Determine Lifespan? (F L Muller & H Van Remmen)
• Oxidative Stress and Ataxia–Telangiectasia (E M Dunner & D J Watters)
• Oxidative Stress and Cardiovascular Disease (S Johar et al.)
• Oxidative Stress, Insulin Resistance, and Cardiovascular Disease (A Ceriello)
• Pathogenesis and Etiology of Down's Syndrome in Relation to Oxidative Stress (S Arbuzova & H Cuckle)
• Oxidative Stress and Ulcerative Colitis: Experimental Evidence and Implications for Treatment (D N Seril et al.)
• Oxidative Stress and Neurodegenerative Disease (K Schüssel et al.)
• Oxidative Stress and Mitochondrial Disease (C-Y Lu et al.)
• Oxidative Stress and Respiratory Disease (R Maselli & G Pelaia)
• Oxidative Stress and Human Reproduction (A Agarwal & S Allamaneni)
• Oxidative Stress and Multistage Carcinogenesis (P C Goswami & K K Singh)
• Oxidative Stress and Cancer Cachexia (G Mantovani & C Madeddu)
• Oxidative Stress in Cancer-Prone Diseases (G Pagano)
• Iron-Induced Carcinogenesis (S Toyokuni)
• Copper and Carcinogenesis (T Theophanides & J Anastassopoulou)
• Arsenic, Oxidative Stress, and Carcinogenesis (M F Hughes & K T Kitchin)
• Estrogen-Induced Carcinogenesis: Importance of Oxidative Stress (H K Bhat)
• Oxidative Stress in HIV Infection (W Dröge)
• Oxidative Stress and Breast Cancer (J Ahn & C B Ambrosone)
• Oxidative Stress and Photocarcinogenesis: Strategies for Prevention (S K Katiyar)
• Oxidative Stress and Coenzyme Q₁₀ Therapy (F L Rosenfeldt et al.)
• Plant-Derived Antioxidants (F H Sarker & Y Li)
• Oxidative Stress and Cancer Therapy (K Pong)
• Nanoscale Antioxidant Therapeutics (T Dziubla et al.)
• Use of Biomarkers of Oxidative Stress in Human Studies (C-Y Chen & J B Blumberg)