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DELIVERY OF PROTEIN AND PEPTIDE DRUGS IN CANCER
edited by Vladimir P Torchilin (Northeastern University, USA)
Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells.
This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, physiology, experimental and clinical oncology and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting as well as in a more specialized topics of using protein and peptide drugs for tumor therapy.
Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences.
Contents:
- Influence of Tumor Physiology on Delivery of Therapeutics (R B
Campbell)
- Enhanced Permeability and Retention (EPR) Effect and Tumor-Selective Delivery of Anticancer Drugs (K Greish et al.)
- Basic Strategies for PEGylation of Peptide and Protein Drugs (G Pasut et al.)
- PEGylated Proteins as Cancer Therapeutics (M Morpurgo et al.)
- PEGylated Proteins in Immunotherapy of Cancer (J F Eliason)
- Silencing Proteins: Nanotechnological Approaches to Deliver of siRNA for Cancer Therapy (R M Schiffelers et al.)
- Anti-Cancer Proteins and Peptides in Liposomes (V Torchilin)
- Folate-Mediated Delivery of Protein and Peptide Drugs into Tumors (J A Reddy et al.)
- Transferrin Receptor Mediated Delivery of Protein and Peptide Drugs into Tumors (J Fahrmeir & M Ogris)
- Transmembrane Delivery of Protein and Peptide Drugs into Cancer Cells (C C Saenz & S F Dowdy)
- Protein and Peptide Drugs to Suppress Tumor Angiogenesis (C Rüegg)
- Utilizing Lymphatic Transport in Enhancing the Delivery of Drugs, Including Proteins, and Peptides, to Metastatic Tumors (E K Wasan & K M Wasan)
- Delivery of Protein and Peptide Drugs to Brain Tumors (H B Newton)
- Protein and Peptide-Based Cancer Gene Therapy (S Chada & R Ramesh)
Readership: Graduate students & academics from cancer therapy, protein &
peptide drugs, drug delivery, & tumor targeting areas; non-experts interested in drug delivery to tumors.
| 392pp |
Pub. date: Apr 2006 |
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