THE ABC TRANSPORTERS OF HUMAN PHYSIOLOGY AND DISEASE
The Genetics and Biochemistry of ATP Binding Cassette
edited by Kenneth J Linton (Imperial College London, UK) & I Barry Holland (Université Paris-Sud, France)
ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins that are likely to be represented in all the cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport of molecules (from small hydrophilic ions to lipids and proteins) across cellular membranes. The human genome encodes 48 ABC transporters and most have been shown to underlie one or more human diseases. This book - that brings together state-of-the-art knowledge on proteins in one volume - will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to diseases. Each of the 14 chapters is written by a leading researcher in the field and includes contributions from Joe Bryan and Lydia Aguilar-Bryan, Kazu Ueda, Jack Riordan and Robert Tampé. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.
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