PHYSICAL BIOLOGY
From Atoms to Medicine
edited by Ahmed H Zewail (California Institute of Technology, USA)
Edited by Nobel Laureate, Ahmed H Zewail, this pioneering book on physical biology includes contributions from four Nobel laureates and other eminent scientists.
This book brings about the confluence of various concepts and tools to address significant problems of our time in physical biology and adjacent disciplines. The volume is structured to provide a broad perspective on current state-of-the-art methods and concepts at the heart of chemical and biological behavior, covering the topics of visualization; theory and computation for complexity; macromolecular function, protein folding, and protein misfolding; molecular recognition; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting, either molecular or by metallic particles. The perspectives are from the point of view of world leaders in physics, chemistry, and biology; and they define potential new frontiers at the interface of these disciplines, including physical, systems, and synthetic biology.
Contents:
- The Preoccupations of Twenty-First-Century Biology (D Baltimore)
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The World as Physics, Mathematics and Nothing Else (A Varshavsky)
- Physical Biology: 4D Visualization of Complexity (A H Zewail)
- Revolutionary Developments from Atomic to Extended Structural Imaging (J M Thomas)
- Physical Biology at the Crossroads (C Bustamante)
- The Challenge of Quasi-Regular Structures in Biology (R D Kornberg)
- The Future of Biological X-Ray Analysis (D C Rees)
- Reinterpreting the Genetic Code: Implications for Macromolecular Design, Evolution and Analysis (D A Tirrell)
- Designing Ligands to Bind Tightly to Proteins (G M Whitesides et al.)
- Biology by the Numbers (R Phillips)
- Eppur si muove (M Parrinello)
- Protein Folding and Beyond: Energy Landscapes and the Organization of Living Matter in Time and Space (P G Wolynes)
- Protein Folding and Misfolding: From Atoms to Organisms (C M Dobson)
- A Systems Approach to Medicine Will Transform Healthcare (L Hood)
- The Neurobiology of Consciousness (C Koch & F Mormann)
- Computer-Aided Drug Discovery: Physics-based Simulations from the Molecular to the Cellular Level (J A McCammom)
- Precision Measurements in Biology (S R Quake)
- Potassium Channels and the Atomic Basis of Selective Ion Conduction (R MacKinnon)
- Symmetry Breaking, Delocalization and Dynamics in Electron Transfer Systems (N S Hush)
- The Initial Value Representation of Semiclassical Theory: A Practical Way for Adding Quantum Effects to Classical Molecular Dynamics Simulations of Complex Molecular Systems (W H Miller)
Readership: Graduate students and researchers in life sciences (structural
biology, genomics, systems biology, molecular biology, neuroscience), biochemistry, physical chemistry, chemical engineering, and biophysics.
| 584pp |
Pub. date: May 2008 |
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